Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity

Abstract Background Childhood maltreatment (CM) is a potential risk factor for some neuropsychiatric disorders in adulthood (e.g. depression and anxiety) alters trajectories of brain development. Accumulating evidence suggests that functional connectivity the limbic system, especially amygdala, highly associated with childhood maltreatment, although not all studies have found this. These inconsistent results may be due to differential alterations amygdala resting-state (rsFC) following maltreatment. Objective Our aim was investigate relationship between rsFC subregions CM severity, as well develop stable rsFC-based model inferring severity CM. Methods In this study, we employed Trauma Questionnaire (CTQ) assess each individual. We explored (i.e. centromedial -CMA, basolateral -BLA, superficial-SFA amygdala) experience discovery dataset n = 110 healthy Chinese participants by linear multiple regression analysis. Subsequent dimensional categorical approach were performed elucidate rsFCs subtypes, respectively. A support vector then conducted validate associations total CTQ scores. Moreover, also verified into another independent replication (n 38). Results findings suggested negatively right superficial perigenual anterior cingulate cortex (pgACC)/postcentral gyrus (PCG) but other two subregions. SFA-pgACC coupling more physical neglect whereas SFA-PCG related emotional neglect. addition, supervised machine learning confirmed using these predictors could stably estimate continuous both datasets. Conclusion The current study supports are which biomarker effects maltreatment-related psychiatric anxiety).